Welcome to the master of Nanoscale Engineering of lyon Retour à l'université de Lyon

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Drug-Delivery Systems

Drug-Delivery Systems (UE S2-4)

This course introduces the applications of nanotechnology for the development of new types of biomedical markers and therapeutic agents, which allow for targeting specific biomolecular and cellular events in a living organism.

Outline of the course

  • Biomedical Imaging
    • Magnetic resonance imaging (MRI) and magnetic nanoparticles
      Principles of MRI, positive and negative contract agents
    • Nuclear imaging and nanometric tracers
      Priciples of positron emission tomography, currently-used radioactive tracers, nanotechnological developments for novel tracers
    • Optical imaging, intravital microscopy and fluorescent markers
      Principles of intravital imaging, classical organic fluorophores, new nanotechnological markers

  • Vectorization and targeted delivery of drugs
    • Principles and challenges
      Different generations of drugs, pharmaceutical nanotechnology
    • Biochemical vectorization
      Colloids and their biological functionalization, precautions depending on the target zone, examples of nanoparticles, current developments
    • Magnetic vectorization
      Physical principles, current trials

  • Therapy
    • Environmentally-sensitive nanostructures (pH, temperature)
    • Magnetically-induced hyperthermia
    • Photodynamic therapy
    • Emergent therapies: IR hyperthermia, neutron therapy

Evaluation

  • graded oral presentation

Prior knowledge



course volume


  • lectures/tutorials:  20 hours
  • ECTS: 2